Nature Communications (Sep 2019)
Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease
- Paraskevi Krashia,
- Alberto Cordella,
- Annalisa Nobili,
- Livia La Barbera,
- Mauro Federici,
- Alessandro Leuti,
- Federica Campanelli,
- Giuseppina Natale,
- Gioia Marino,
- Valeria Calabrese,
- Francescangelo Vedele,
- Veronica Ghiglieri,
- Barbara Picconi,
- Giulia Di Lazzaro,
- Tommaso Schirinzi,
- Giulia Sancesario,
- Nicolas Casadei,
- Olaf Riess,
- Sergio Bernardini,
- Antonio Pisani,
- Paolo Calabresi,
- Maria Teresa Viscomi,
- Charles Nicholas Serhan,
- Valerio Chiurchiù,
- Marcello D’Amelio,
- Nicola Biagio Mercuri
Affiliations
- Paraskevi Krashia
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Alberto Cordella
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Annalisa Nobili
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Livia La Barbera
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Mauro Federici
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Alessandro Leuti
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Federica Campanelli
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Giuseppina Natale
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Gioia Marino
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Valeria Calabrese
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Francescangelo Vedele
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Veronica Ghiglieri
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Barbara Picconi
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Giulia Di Lazzaro
- Department of Systems Medicine, University of Rome ‘Tor Vergata’
- Tommaso Schirinzi
- Department of Systems Medicine, University of Rome ‘Tor Vergata’
- Giulia Sancesario
- Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation
- Nicolas Casadei
- Institute of Medical Genetics and Applied Genomics, University of Tübingen
- Olaf Riess
- Institute of Medical Genetics and Applied Genomics, University of Tübingen
- Sergio Bernardini
- Department of Experimental Medicine and Surgery, University of Rome ‘Tor Vergata’
- Antonio Pisani
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Paolo Calabresi
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Maria Teresa Viscomi
- Institute of Histology and Embryology, Università Cattolica del Sacro Cuore
- Charles Nicholas Serhan
- Center for Experimental Therapeutics and Reperfusion Injury, Department of Anaesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Valerio Chiurchiù
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Marcello D’Amelio
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Nicola Biagio Mercuri
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- DOI
- https://doi.org/10.1038/s41467-019-11928-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 19
Abstract
Resolvins are endogenous lipids with pro-resolving activity. Here the authors find that rats overexpressing human α-synuclein show defects in dopamine signalling before dopamine cell loss, and that this is associated with low Resolvin D1 levels and neuroinflammation.
