Nature Communications (Sep 2019)

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease

  • Paraskevi Krashia,
  • Alberto Cordella,
  • Annalisa Nobili,
  • Livia La Barbera,
  • Mauro Federici,
  • Alessandro Leuti,
  • Federica Campanelli,
  • Giuseppina Natale,
  • Gioia Marino,
  • Valeria Calabrese,
  • Francescangelo Vedele,
  • Veronica Ghiglieri,
  • Barbara Picconi,
  • Giulia Di Lazzaro,
  • Tommaso Schirinzi,
  • Giulia Sancesario,
  • Nicolas Casadei,
  • Olaf Riess,
  • Sergio Bernardini,
  • Antonio Pisani,
  • Paolo Calabresi,
  • Maria Teresa Viscomi,
  • Charles Nicholas Serhan,
  • Valerio Chiurchiù,
  • Marcello D’Amelio,
  • Nicola Biagio Mercuri

DOI
https://doi.org/10.1038/s41467-019-11928-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 19

Abstract

Read online

Resolvins are endogenous lipids with pro-resolving activity. Here the authors find that rats overexpressing human α-synuclein show defects in dopamine signalling before dopamine cell loss, and that this is associated with low Resolvin D1 levels and neuroinflammation.