Nature Communications (Jun 2018)
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
- Juliane Hitzel,
- Eunjee Lee,
- Yi Zhang,
- Sofia Iris Bibli,
- Xiaogang Li,
- Sven Zukunft,
- Beatrice Pflüger,
- Jiong Hu,
- Christoph Schürmann,
- Andrea Estefania Vasconez,
- James A. Oo,
- Adelheid Kratzer,
- Sandeep Kumar,
- Flávia Rezende,
- Ivana Josipovic,
- Dominique Thomas,
- Hector Giral,
- Yannick Schreiber,
- Gerd Geisslinger,
- Christian Fork,
- Xia Yang,
- Fragiska Sigala,
- Casey E. Romanoski,
- Jens Kroll,
- Hanjoong Jo,
- Ulf Landmesser,
- Aldons J. Lusis,
- Dmitry Namgaladze,
- Ingrid Fleming,
- Matthias S. Leisegang,
- Jun Zhu,
- Ralf P. Brandes
Affiliations
- Juliane Hitzel
- Institute for Cardiovascular Physiology, Goethe University
- Eunjee Lee
- Icahn Institute of Genomics and Multiscale Biology, Mount Sinai Icahn School of Medicine
- Yi Zhang
- Icahn Institute of Genomics and Multiscale Biology, Mount Sinai Icahn School of Medicine
- Sofia Iris Bibli
- German Center for Cardiovascular Research (DZHK) (Partner site Rhine-Main)
- Xiaogang Li
- Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University
- Sven Zukunft
- German Center for Cardiovascular Research (DZHK) (Partner site Rhine-Main)
- Beatrice Pflüger
- Institute for Cardiovascular Physiology, Goethe University
- Jiong Hu
- German Center for Cardiovascular Research (DZHK) (Partner site Rhine-Main)
- Christoph Schürmann
- Institute for Cardiovascular Physiology, Goethe University
- Andrea Estefania Vasconez
- Institute for Cardiovascular Physiology, Goethe University
- James A. Oo
- Institute for Cardiovascular Physiology, Goethe University
- Adelheid Kratzer
- Department of Cardiology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin
- Sandeep Kumar
- Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- Flávia Rezende
- Institute for Cardiovascular Physiology, Goethe University
- Ivana Josipovic
- Institute for Cardiovascular Physiology, Goethe University
- Dominique Thomas
- Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, Faculty of Medicine, Goethe University
- Hector Giral
- Department of Cardiology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin
- Yannick Schreiber
- Fraunhofer Institute of Molecular Biology and Applied Ecology—Project Group Translational Medicine and Pharmacology (IME-TMP)
- Gerd Geisslinger
- Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, Faculty of Medicine, Goethe University
- Christian Fork
- Institute for Cardiovascular Physiology, Goethe University
- Xia Yang
- Department of Integrative Biology and Physiology, University of California
- Fragiska Sigala
- 1st Department of Propaedeutic Surgery, University of Athens Medical School, Hippocration Hospital
- Casey E. Romanoski
- Department of Cellular and Molecular Medicine, University of Arizona
- Jens Kroll
- Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University
- Hanjoong Jo
- Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- Ulf Landmesser
- Department of Cardiology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin
- Aldons J. Lusis
- Departments of Medicine, Microbiology and Human Genetics, University of California
- Dmitry Namgaladze
- Institute of Biochemistry I, Goethe University
- Ingrid Fleming
- German Center for Cardiovascular Research (DZHK) (Partner site Rhine-Main)
- Matthias S. Leisegang
- Institute for Cardiovascular Physiology, Goethe University
- Jun Zhu
- Icahn Institute of Genomics and Multiscale Biology, Mount Sinai Icahn School of Medicine
- Ralf P. Brandes
- Institute for Cardiovascular Physiology, Goethe University
- DOI
- https://doi.org/10.1038/s41467-018-04602-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 18
Abstract
During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolism towards production of purines and thus compensates for their loss.
