Nature Communications (Dec 2022)
Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease
- Ana Sofía Ríos,
- Simón Oxenford,
- Clemens Neudorfer,
- Konstantin Butenko,
- Ningfei Li,
- Nanditha Rajamani,
- Alexandre Boutet,
- Gavin J. B. Elias,
- Jurgen Germann,
- Aaron Loh,
- Wissam Deeb,
- Fuyixue Wang,
- Kawin Setsompop,
- Bryan Salvato,
- Leonardo Brito de Almeida,
- Kelly D. Foote,
- Robert Amaral,
- Paul B. Rosenberg,
- David F. Tang-Wai,
- David A. Wolk,
- Anna D. Burke,
- Stephen Salloway,
- Marwan N. Sabbagh,
- M. Mallar Chakravarty,
- Gwenn S. Smith,
- Constantine G. Lyketsos,
- Michael S. Okun,
- William S. Anderson,
- Zoltan Mari,
- Francisco A. Ponce,
- Andres M. Lozano,
- Andreas Horn
Affiliations
- Ana Sofía Ríos
- Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Simón Oxenford
- Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Clemens Neudorfer
- Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Konstantin Butenko
- Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Ningfei Li
- Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Nanditha Rajamani
- Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Alexandre Boutet
- Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto
- Gavin J. B. Elias
- Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto
- Jurgen Germann
- Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto
- Aaron Loh
- Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto
- Wissam Deeb
- UMass Chan Medical School, Department of Neurology
- Fuyixue Wang
- Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital
- Kawin Setsompop
- Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital
- Bryan Salvato
- University of Florida Health Jacksonville
- Leonardo Brito de Almeida
- Norman Fixel Institute for Neurological Diseases, Departments of Neurology and Neurosurgery, University of Florida
- Kelly D. Foote
- Norman Fixel Institute for Neurological Diseases, Departments of Neurology and Neurosurgery, University of Florida
- Robert Amaral
- Cerebral Imaging Centre, Douglas Research Centre
- Paul B. Rosenberg
- Department of Psychiatry and Behavioral Sciences and Richman Family Precision Medicine Center of Excellence, School of Medicine, Johns Hopkins University
- David F. Tang-Wai
- Krembil Research Institute, University of Toronto
- David A. Wolk
- Department of Neurology, University of Pennsylvania
- Anna D. Burke
- Barrow Neurological Institute
- Stephen Salloway
- Department of Psychiatry and Human Behavior and Neurology, Alpert Medical School of Brown University
- Marwan N. Sabbagh
- Barrow Neurological Institute
- M. Mallar Chakravarty
- Cerebral Imaging Centre, Douglas Research Centre
- Gwenn S. Smith
- Department of Psychiatry and Behavioral Sciences and Richman Family Precision Medicine Center of Excellence, School of Medicine, Johns Hopkins University
- Constantine G. Lyketsos
- Department of Psychiatry and Behavioral Sciences and Richman Family Precision Medicine Center of Excellence, School of Medicine, Johns Hopkins University
- Michael S. Okun
- Norman Fixel Institute for Neurological Diseases, Departments of Neurology and Neurosurgery, University of Florida
- William S. Anderson
- Johns Hopkins School of Medicine
- Zoltan Mari
- Johns Hopkins School of Medicine
- Francisco A. Ponce
- Barrow Neurological Institute
- Andres M. Lozano
- Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto
- Andreas Horn
- Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- DOI
- https://doi.org/10.1038/s41467-022-34510-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Deep brain stimulation has been investigated as a potential treatment for cognitive impairments in Alzheimer’s disease. Here the authors carry out post hoc analysis of multi-center cohorts to investigate the anatomical and functional correlates of effective deep brain stimulation, and find that stimulating circuit of Papez, fornix and bed nucleus of the stria terminalis, and a multi-region functional network, were associated with clinical improvement.
