Plasma Brain-Derived Neurotrophic Factor Levels Of Patients Undergoing Hemodialysis And Peritoneal Dialysis

Abstract

Recent studies have shown that brain-derived neurotrophic factor (BDNF) is associated with neurotoxic, inflammatory and nutritional status . The pulpose of this study is to investigate the changes in plasma BDNF concentration that were induced by chronic uremic condition. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in pre-hemodialysis (pre-HD), peritoneal dialysis (PD) patients and in a control group. The plasma BDNF concentrations of pre-HD, PD patients were significantly higher compared with those of controls (856.3 ± 879.1, 1167.9 ± 647.5 versus 403.1 ± 288.9 pg/ml, respectively). The plasma BDNF in dialysis patients was positively correlated with high-sensitivity C reactive protein (hs-CRP) and with serum albumin negatively. Plasma BDNF hs-CRP Albumin r p r p Pre-HD 0.321 0.025 -0.298 0.021 PD 0.414 0.070 -0.527 0.008 Pre-HD + PD 0.446 0.001 -0.453 0.001 In conclusion, BDNF might plays some role in the neurotoxicity of uremia and associated with inflammation and malnutrition in dialysis patients.