Nature Communications (Oct 2018)
RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer
- Hanna Yang,
- Dongwan Hong,
- Soo Young Cho,
- Young Soo Park,
- Woo Ri Ko,
- Ju Hee Kim,
- Hoon Hur,
- Jongkeun Lee,
- Su-Jin Kim,
- Sun Young Kwon,
- Jae-Hyuk Lee,
- Do Youn Park,
- Kyu Sang Song,
- Heekyung Chang,
- Min-Hee Ryu,
- Kye Soo Cho,
- Jeong Won Kang,
- Myeong-Cherl Kook,
- Nina Thiessen,
- An He,
- Andy Mungall,
- Sang-Uk Han,
- Hark Kyun Kim
Affiliations
- Hanna Yang
- National Cancer Center
- Dongwan Hong
- National Cancer Center
- Soo Young Cho
- National Cancer Center
- Young Soo Park
- Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine
- Woo Ri Ko
- National Cancer Center
- Ju Hee Kim
- National Cancer Center
- Hoon Hur
- Department of Surgery, Ajou University School of Medicine
- Jongkeun Lee
- National Cancer Center
- Su-Jin Kim
- Department of Pathology, Dong-A University College of Medicine
- Sun Young Kwon
- Department of Pathology, Keimyung University School of Medicine
- Jae-Hyuk Lee
- Department of Pathology, Chonnam National University Medical School
- Do Youn Park
- Department of Pathology and BioMedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine
- Kyu Sang Song
- Department of Pathology, School of Medicine, Chungnam National University
- Heekyung Chang
- Department of Pathology, Kosin University College of Medicine
- Min-Hee Ryu
- Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine
- Kye Soo Cho
- National Cancer Center
- Jeong Won Kang
- National Cancer Center
- Myeong-Cherl Kook
- National Cancer Center
- Nina Thiessen
- British Columbia Cancer Agency
- An He
- British Columbia Cancer Agency
- Andy Mungall
- British Columbia Cancer Agency
- Sang-Uk Han
- Department of Surgery, Ajou University School of Medicine
- Hark Kyun Kim
- National Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-06747-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Diffuse Gastric Cancer (DGC) is increasingly being considered separate to intestinal type gastric cancer; several fusions events have been reported as drivers of the disease but few of those have been subsequently validated. Here the authors perform RNA-seq on early-onset DGC patients who had not been treated with chemotherapy or radiation and identify a previously unknown fusion.
