Nature Communications (Jul 2017)
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm
- Marina Cerrone,
- Jerome Montnach,
- Xianming Lin,
- Yan-Ting Zhao,
- Mingliang Zhang,
- Esperanza Agullo-Pascual,
- Alejandra Leo-Macias,
- Francisco J. Alvarado,
- Igor Dolgalev,
- Thomas V. Karathanos,
- Kabir Malkani,
- Chantal J.M. Van Opbergen,
- Joanne J.A. van Bavel,
- Hua-Qian Yang,
- Carolina Vasquez,
- David Tester,
- Steven Fowler,
- Fengxia Liang,
- Eli Rothenberg,
- Adriana Heguy,
- Gregory E. Morley,
- William A. Coetzee,
- Natalia A. Trayanova,
- Michael J. Ackerman,
- Toon A.B. van Veen,
- Hector H. Valdivia,
- Mario Delmar
Affiliations
- Marina Cerrone
- Leon H Charney Division of Cardiology, NYU School of Medicine
- Jerome Montnach
- Leon H Charney Division of Cardiology, NYU School of Medicine
- Xianming Lin
- Leon H Charney Division of Cardiology, NYU School of Medicine
- Yan-Ting Zhao
- Center for Arrhythmia Research, Division of Cardiology, University of Michigan
- Mingliang Zhang
- Leon H Charney Division of Cardiology, NYU School of Medicine
- Esperanza Agullo-Pascual
- Leon H Charney Division of Cardiology, NYU School of Medicine
- Alejandra Leo-Macias
- Leon H Charney Division of Cardiology, NYU School of Medicine
- Francisco J. Alvarado
- Department of Molecular and Integrative Physiology, University of Michigan
- Igor Dolgalev
- Genome Technology Center, NYU School of Medicine
- Thomas V. Karathanos
- Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University
- Kabir Malkani
- Leon H Charney Division of Cardiology, NYU School of Medicine
- Chantal J.M. Van Opbergen
- Department of Medical Physiology Division of Heart & Lungs University Medical Centre Utrecht
- Joanne J.A. van Bavel
- Department of Medical Physiology Division of Heart & Lungs University Medical Centre Utrecht
- Hua-Qian Yang
- Department of Pediatrics, NYU School of Medicine
- Carolina Vasquez
- Leon H Charney Division of Cardiology, NYU School of Medicine
- David Tester
- Departments of Cardiovascular Diseases/Division of Heart Rhythm Services, Windland Smith Rice Sudden Death Genomics Laboratory
- Steven Fowler
- Leon H Charney Division of Cardiology, NYU School of Medicine
- Fengxia Liang
- Department of Cell Biology and Microscopy Core, NYU School of Medicine
- Eli Rothenberg
- Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine
- Adriana Heguy
- Genome Technology Center, NYU School of Medicine
- Gregory E. Morley
- Leon H Charney Division of Cardiology, NYU School of Medicine
- William A. Coetzee
- Departments of Pediatrics, Physiology & Neuroscience and Biochemistry and Molecular Pharmacology, NYU School of Medicine
- Natalia A. Trayanova
- Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University
- Michael J. Ackerman
- Departments of Cardiovascular Diseases/Division of Heart Rhythm Services, Windland Smith Rice Sudden Death Genomics Laboratory
- Toon A.B. van Veen
- Department of Medical Physiology Division of Heart & Lungs University Medical Centre Utrecht
- Hector H. Valdivia
- Center for Arrhythmia Research, Division of Cardiology, University of Michigan
- Mario Delmar
- Leon H Charney Division of Cardiology, NYU School of Medicine
- DOI
- https://doi.org/10.1038/s41467-017-00127-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
It is believed that mutations in desmosomal adhesion complex protein plakophilin 2 (PKP2) cause arrhythmia due to loss of cell-cell communication. Here the authors show that PKP2 controls the expression of proteins involved in calcium cycling in adult mouse hearts, and that lack of PKP2 can cause arrhythmia in a structurally normal heart.
