Vestnik Transplantologii i Iskusstvennyh Organov (Sep 2018)

Diagnostic possibilities of using micro-RNA for kidney transplantation

  • I. A. Pirozhkov,
  • M. E. Malyshev,
  • O. N. Reznik,
  • V. A. Manukovsky,
  • A. E. Skvortsov

DOI
https://doi.org/10.15825/1995-1191-2018-3-87-94
Journal volume & issue
Vol. 20, no. 3
pp. 87 – 94

Abstract

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Allogeneic kidney transplantation is the optimal approach for the treatment of patients with terminal stage of chronic kidney disease. Moreover, post-transplant monitoring and optimization of immunosuppressive therapy with early non-invasive molecular-biological markers can significantly improve the long-term outcome of transplantation. As markers of damage to the kidney transplant, it is proposed to use micro-RNAs that play a fundamental role in the regulation of the activity of various genes. The level of expression of micro-RNA in different tissues can correlate with certain pathological conditions. In this review, the literature data on the study of the perspectives for the use of micro-RNA as biomarkers of the post-transplantation period in kidney transplant recipients are considered.

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