Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures

Jiao Li; Jakob Seidlitz; John Suckling; Feiyang Fan; Gong-Jun Ji; Yao Meng; Siqi Yang; Kai Wang; Jiang Qiu; Huafu Chen; Wei Liao

doi:10.1038/s41467-021-21943-5

Nature Communications (Mar 2021)

Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures

Jiao Li,
Jakob Seidlitz,
John Suckling,
Feiyang Fan,
Gong-Jun Ji,
Yao Meng,
Siqi Yang,
Kai Wang,
Jiang Qiu,
Huafu Chen,
Wei Liao

Affiliations

Jiao Li: The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China
Jakob Seidlitz: Children’s Hospital of Philadelphia, Department of Child and Adolescent Psychiatry and Behavioral Science
John Suckling: University of Cambridge, Department of Psychiatry
Feiyang Fan: The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China
Gong-Jun Ji: Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University
Yao Meng: The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China
Siqi Yang: The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China
Kai Wang: Department of Medical Psychology, Chaohu Clinical Medical College, Anhui Medical University
Jiang Qiu: School of Psychology, Southwest University
Huafu Chen: The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China
Wei Liao: The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China

DOI: https://doi.org/10.1038/s41467-021-21943-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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The correlation between brain structural changes in major depressive disorder (MDD) and gene expression is unclear. Here, the authors explore the correlation between cell type-specific gene expression changes and cortical structural difference in individuals with major depressive disorder.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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