Neural Regeneration Research (Jan 2021)

Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke

  • Wan Zhang,
  • Tian Tian,
  • Shao-Xin Gong,
  • Wen-Qian Huang,
  • Qin-Yi Zhou,
  • Ai-Ping Wang,
  • Ying Tian

Journal volume & issue
Vol. 16, no. 1
pp. 6 – 11


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Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic stroke. Microglial activation and polarization, and the inflammatory response mediated by these cells play important roles in the development, progression and outcome of brain injury after ischemic stroke. Currently, there is no effective strategy for treating ischemic stroke in clinical practice. Therefore, it is clinically important to study the role and regulation of microglia in stroke. In this review, we discuss the involvement of microglia in the neuroinflammatory process in ischemic stroke, with the aim of providing a better understanding of the relationship between ischemic stroke and microglia.