Nature Communications (Sep 2019)
The transferability of lipid loci across African, Asian and European cohorts
- Karoline Kuchenbaecker,
- Nikita Telkar,
- Theresa Reiker,
- Robin G. Walters,
- Kuang Lin,
- Anders Eriksson,
- Deepti Gurdasani,
- Arthur Gilly,
- Lorraine Southam,
- Emmanouil Tsafantakis,
- Maria Karaleftheri,
- Janet Seeley,
- Anatoli Kamali,
- Gershim Asiki,
- Iona Y. Millwood,
- Michael Holmes,
- Huaidong Du,
- Yu Guo,
- Meena Kumari,
- George Dedoussis,
- Liming Li,
- Zhengming Chen,
- Manjinder S. Sandhu,
- Eleftheria Zeggini,
- Understanding Society Scientific Group
Affiliations
- Karoline Kuchenbaecker
- Division of Psychiatry, University College of London
- Nikita Telkar
- Department of Genetics, Evolution and Environment, University College London
- Theresa Reiker
- Department of Human Genetics, Wellcome Sanger Institute
- Robin G. Walters
- Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford
- Kuang Lin
- Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford
- Anders Eriksson
- Department of Medical and Molecular Genetics, King’s College London
- Deepti Gurdasani
- Department of Human Genetics, Wellcome Sanger Institute
- Arthur Gilly
- Department of Human Genetics, Wellcome Sanger Institute
- Lorraine Southam
- Department of Human Genetics, Wellcome Sanger Institute
- Emmanouil Tsafantakis
- Anogia Medical Centre
- Maria Karaleftheri
- Echinos Medical Centre, Echinos
- Janet Seeley
- Department of Global Health and Development, London School of Hygiene & Tropical Medicine
- Anatoli Kamali
- Medical Research1 Council/Uganda Virus Research Institute and London School of Hygiene (MRC/UVRI and LSHTM), Uganda Research Unit
- Gershim Asiki
- Medical Research1 Council/Uganda Virus Research Institute and London School of Hygiene (MRC/UVRI and LSHTM), Uganda Research Unit
- Iona Y. Millwood
- Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford
- Michael Holmes
- Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford
- Huaidong Du
- Medical Research Council Population Health Research Unit (MRC PHRU), Nuffield Department of Population Health, University of Oxford
- Yu Guo
- Chinese Academy of Medical Sciences
- Meena Kumari
- Institute for Social and Economic Research, University of Essex
- George Dedoussis
- Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens
- Liming Li
- Department of Epidemiology and Biostatistics, School of Public Health, Peking University
- Zhengming Chen
- Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford
- Manjinder S. Sandhu
- Department of Medicine, University of Cambridge
- Eleftheria Zeggini
- Department of Human Genetics, Wellcome Sanger Institute
- Understanding Society Scientific Group
- DOI
- https://doi.org/10.1038/s41467-019-12026-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
The majority of published GWAS was performed in European ancestry populations. Here, Kuchenbaecker et al., test to which extent lipid loci are shared and find that the major lipid loci are mostly transferrable between Europeans and Asians while there are notable exceptions for African populations.
