Nature Communications (Jan 2020)

Ultracompact 3D microfluidics for time-resolved structural biology

  • Juraj Knoška,
  • Luigi Adriano,
  • Salah Awel,
  • Kenneth R. Beyerlein,
  • Oleksandr Yefanov,
  • Dominik Oberthuer,
  • Gisel E. Peña Murillo,
  • Nils Roth,
  • Iosifina Sarrou,
  • Pablo Villanueva-Perez,
  • Max O. Wiedorn,
  • Fabian Wilde,
  • Saša Bajt,
  • Henry N. Chapman,
  • Michael Heymann

DOI
https://doi.org/10.1038/s41467-020-14434-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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There is a need for more robust sample delivery methods for serial crystallography. Here the authors present the design and characterization of ultracompact 3D microfluidic devices that can be printed, which require less sample, have a lower background signal and allow 3D mixing for time resolved experiments.