Nature Communications (Mar 2018)

Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow

  • Yafeng Zhu,
  • Lukas M. Orre,
  • Henrik J. Johansson,
  • Mikael Huss,
  • Jorrit Boekel,
  • Mattias Vesterlund,
  • Alejandro Fernandez-Woodbridge,
  • Rui M. M. Branca,
  • Janne Lehtiö

DOI
https://doi.org/10.1038/s41467-018-03311-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Proteogenomics enables the discovery of protein coding regions and disease-relevant mutations but their verification remains challenging. Here, the authors combine peptide discovery, curation and validation in an integrated proteogenomics workflow, robustly identifying unknown coding regions and mutations.