A mechanism for CO regulation of ion channels

Sofia M. Kapetanaki; Mark J. Burton; Jaswir Basran; Chiasa Uragami; Peter C. E. Moody; John S. Mitcheson; Ralf Schmid; Noel W. Davies; Pierre Dorlet; Marten H. Vos; Nina M. Storey; Emma Raven

doi:10.1038/s41467-018-03291-z

Nature Communications (Mar 2018)

Affiliations

Sofia M. Kapetanaki: Department of Chemistry and Leicester Institute of Structural and Chemical Biology, University of Leicester
Mark J. Burton: Department of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester
Jaswir Basran: Department of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester
Chiasa Uragami: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay
Peter C. E. Moody: Department of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester
John S. Mitcheson: Department of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester
Ralf Schmid: Department of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester
Noel W. Davies: Department of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester
Pierre Dorlet: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay
Marten H. Vos: LOB, Ecole Polytechnique, CNRS, INSERM, Université Paris-Saclay
Nina M. Storey: Department of Molecular and Cell Biology and Leicester Institute of Structural and Chemical Biology, University of Leicester
Emma Raven: Department of Chemistry and Leicester Institute of Structural and Chemical Biology, University of Leicester

DOI: https://doi.org/10.1038/s41467-018-03291-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Despite being highly toxic, carbon monoxide (CO) is also essential as an intracellular signalling molecule, but CO-dependent signalling is poorly understood. Here, authors employ spectroscopic and electrophysiology methods and find that CO activates KATP channels via SUR2A, a heme-regulated receptor.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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