Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL

Bandish Kapadia; Nahid M. Nanaji; Kavita Bhalla; Binny Bhandary; Rena Lapidus; Afshin Beheshti; Andrew M. Evens; Ronald B. Gartenhaus

doi:10.1038/s41467-018-03028-y

Nature Communications (Feb 2018)

Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL

Bandish Kapadia,
Nahid M. Nanaji,
Kavita Bhalla,
Binny Bhandary,
Rena Lapidus,
Afshin Beheshti,
Andrew M. Evens,
Ronald B. Gartenhaus

Affiliations

Bandish Kapadia: Department of Medicine, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland
Nahid M. Nanaji: Department of Veteran Affairs, Maryland Healthcare System
Kavita Bhalla: Department of Medicine, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland
Binny Bhandary: Department of Medicine, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland
Rena Lapidus: Department of Medicine, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland
Afshin Beheshti: Division of Hematology/Oncology, Molecular Oncology Research Institute, Tufts Medical Center
Andrew M. Evens: Division of Hematology/Oncology, Molecular Oncology Research Institute, Tufts Medical Center
Ronald B. Gartenhaus: Department of Medicine, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland

DOI: https://doi.org/10.1038/s41467-018-03028-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Aberrant protein translation and uncontrolled lipid metabolism are hallmarks of cancer growth. Here, in diffuse large B-cell lymphoma, the authors show that fatty acid synthase increases USP11 interaction with and stability of eIF4B via PI3K-S6Kinase signaling, promoting oncogenic protein translation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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