Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

Xin Wei; Afsar Khan; Da Song; Zhi Dai; Ya-Ping Liu; Hao-Fei Yu; Bei Wang; Pei-Feng Zhu; Cai-Feng Ding; Xu-Dong Zhao; Yi-Fen Wang; Xiao-Dong Luo

doi:10.1007/s13659-017-0137-7

Natural Products and Bioprospecting (Jun 2017)

Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan

Xin Wei,
Afsar Khan,
Da Song,
Zhi Dai,
Ya-Ping Liu,
Hao-Fei Yu,
Bei Wang,
Pei-Feng Zhu,
Cai-Feng Ding,
Xu-Dong Zhao,
Yi-Fen Wang,
Xiao-Dong Luo

Affiliations

Xin Wei: State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences
Afsar Khan: State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences
Da Song: Yunnan College of Business Management
Zhi Dai: Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology
Ya-Ping Liu: State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences
Hao-Fei Yu: State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences
Bei Wang: State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences
Pei-Feng Zhu: State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences
Cai-Feng Ding: State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences
Xu-Dong Zhao: Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology
Yi-Fen Wang: State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences
Xiao-Dong Luo: State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences

DOI: https://doi.org/10.1007/s13659-017-0137-7
Journal volume & issue: Vol. 7, no. 4
pp. 323 – 327

Abstract

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Abstract Three new pyridine type alkaloids, (−)-vinmajpyridines A–C (1–3), along with two known alkaloids, have been isolated from the aerial parts of Vinca major cultivated in Pakistan. Their structures have been elucidated by means of NMR and HRESIMS spectroscopic data. The new alkaloids were evaluated for their cytotoxicity against glioma initiating cell lines (GITC-3# and GITC-18#), glioblastoma cell lines (U-87MG and T98G), and lung cancer cell line A-549, but none of them was active at 20 μg/mL concentration.

Published in Natural Products and Bioprospecting

ISSN: 2192-2195 (Print); 2192-2209 (Online)
Publisher: SpringerOpen
Country of publisher: Germany
LCC subjects: Science: Botany
Website: http://www.springer.com/13659

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