Elevated Serum Neopterin Levels in Acute Rheumatic Fever

Samsonov M.Y.; Reibnegger G.; Nassonov E.L.; Nassonova V.A; Wachter H.; Fuchs D.

doi:10.1515/pteridines.1993.4.1.39

Pteridines (Feb 1993)

Elevated Serum Neopterin Levels in Acute Rheumatic Fever

Samsonov M.Y.,
Reibnegger G.,
Nassonov E.L.,
Nassonova V.A,
Wachter H.,
Fuchs D.

Affiliations

Samsonov M.Y.: Institute of Clinical Cardiology. Cardiology Research Centre, 3rd Cherepkovskaya 15a, 121552, Moscow. Russia
Reibnegger G.: Institute of Medical Chemistry and Biochemistry. University of Innsbruck, Fritz Pregl Str. 3, A-6020 Innsbruck, Austria
Nassonov E.L.: Institute of Clinical Cardiology. Cardiology Research Centre, 3rd Cherepkovskaya 15a, 121552, Moscow. Russia
Nassonova V.A: Institute of Rheumatology. Kashirskoye Schosse 34a, 115552. Moscow. Russia
Wachter H.: Institute of Medical Chemistry and Biochemistry. University of Innsbruck, Fritz Pregl Str. 3, A-6020 Innsbruck, Austria
Fuchs D.: Institute of Medical Chemistry and Biochemistry. University of Innsbruck, Fritz Pregl Str. 3, A-6020 Innsbruck, Austria

DOI: https://doi.org/10.1515/pteridines.1993.4.1.39
Journal volume & issue: Vol. 4, no. 1
pp. 39 – 42

Abstract

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A link between acute rheumatic fever (ARF) and autoimmune disorders has been postulated. To investigate this relationship. we performed radioimmunoassay measurements of serum neoplerin levels in patients with ARF. Twenty-five young men with ARF were included in our study. Patients were investigated on 3-7 days after the onset of symptoms and on the 30th-35th days after onset. Serum neopterin levels were elevated (>8.7 nmol/L) in 17 out of 25 patients with ARF. Mean neopterin concentration was significantly higher in ARF patients (10.9± 3.9 nmol/L) compared to healthy controls (5.2± 2.1 nmol/L; p<0.001). After treatment of patients .with antibiotics and indometacin, neopterin levels were normal in 16 of 23 patients. There was an association between higher neopterin concentration and development of aortic incompetence during follow-up (p<0.05). Also a significant correlation between neopterin and haemoglobin levels was observed (R= - 0.40. p = 0.(2). The increased neopterin levels indicate enhanced cellular immune activation in patients with ARF. The data suggest that serum neopterin might he a predictive marker of aortic valve lesions in patients with ARF.

acute rheumatic fever. valve lesion. immune activation. haemoglohin. neopterin

Published in Pteridines

ISSN: 0933-4807 (Print); 2195-4720 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Chemistry: Crystallography
Website: https://www.degruyter.com/view/j/pteridines

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