Nature Communications (Apr 2022)

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

  • Daniel J. Ham,
  • Anastasiya Börsch,
  • Kathrin Chojnowska,
  • Shuo Lin,
  • Aurel B. Leuchtman,
  • Alexander S. Ham,
  • Marco Thürkauf,
  • Julien Delezie,
  • Regula Furrer,
  • Dominik Burri,
  • Michael Sinnreich,
  • Christoph Handschin,
  • Lionel A. Tintignac,
  • Mihaela Zavolan,
  • Nitish Mittal,
  • Markus A. Rüegg

DOI
https://doi.org/10.1038/s41467-022-29714-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 20

Abstract

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The anti-aging intervention calorie restriction (CR) is thought to act via the nutrient-sensing multiprotein complex mTORC1. Here the authors show that the mTORC1-inhibitor rapamycin and CR use largely distinct mechanisms to slow mouse muscle aging.