Pathogens and Immunity (Dec 2022)

B-Cell Responses to Sars-Cov-2 mRNA Vaccines

  • Lela Kardava,
  • Clarisa Buckner,
  • Susan Moir

DOI
https://doi.org/10.20411/pai.v7i2.550
Journal volume & issue
Vol. 7, no. 2

Abstract

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Most vaccines against viral pathogens protect through the acquisition of immunological memory from long-lived plasma cells that produce antibodies and memory B cells that can rapidly respond upon an encounter with the pathogen or its variants. The COVID-19 pandemic and rapid deployment of effective vaccines have provided an unprecedented opportunity to study the immune response to a new yet rapidly evolving pathogen. Here we review the scientific literature and our efforts to understand antibody and B-cell responses to SARS-CoV-2 vaccines, the effect of SARS-CoV-2 infection on both primary and secondary immune responses, and how repeated exposures may impact outcomes.

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