Nature Communications (Mar 2022)
Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma
- Karin D. Prummel,
- Helena L. Crowell,
- Susan Nieuwenhuize,
- Eline C. Brombacher,
- Stephan Daetwyler,
- Charlotte Soneson,
- Jelena Kresoja-Rakic,
- Agnese Kocere,
- Manuel Ronner,
- Alexander Ernst,
- Zahra Labbaf,
- David E. Clouthier,
- Anthony B. Firulli,
- Héctor Sánchez-Iranzo,
- Sundar R. Naganathan,
- Rebecca O’Rourke,
- Erez Raz,
- Nadia Mercader,
- Alexa Burger,
- Emanuela Felley-Bosco,
- Jan Huisken,
- Mark D. Robinson,
- Christian Mosimann
Affiliations
- Karin D. Prummel
- Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus
- Helena L. Crowell
- Department of Molecular Life Sciences, University of Zurich
- Susan Nieuwenhuize
- Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus
- Eline C. Brombacher
- Department of Molecular Life Sciences, University of Zurich
- Stephan Daetwyler
- Max Planck Institute of Molecular Cell Biology and Genetics
- Charlotte Soneson
- Department of Molecular Life Sciences, University of Zurich
- Jelena Kresoja-Rakic
- Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus
- Agnese Kocere
- Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus
- Manuel Ronner
- Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zurich
- Alexander Ernst
- Institute of Anatomy, University of Bern
- Zahra Labbaf
- Institute for Cell Biology, ZMBE
- David E. Clouthier
- Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus
- Anthony B. Firulli
- Herman B Wells Center for Pediatric Research, Departments of Pediatrics, Anatomy and Medical and Molecular Genetics, Indiana Medical School
- Héctor Sánchez-Iranzo
- Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII)
- Sundar R. Naganathan
- Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne
- Rebecca O’Rourke
- Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus
- Erez Raz
- Institute for Cell Biology, ZMBE
- Nadia Mercader
- Institute of Anatomy, University of Bern
- Alexa Burger
- Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus
- Emanuela Felley-Bosco
- Laboratory of Molecular Oncology, Department of Thoracic Surgery, University Hospital Zurich
- Jan Huisken
- Max Planck Institute of Molecular Cell Biology and Genetics
- Mark D. Robinson
- Department of Molecular Life Sciences, University of Zurich
- Christian Mosimann
- Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus
- DOI
- https://doi.org/10.1038/s41467-022-29311-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
The mesothelium supports homeostasis and regeneration, yet its development origins remain unclear. Here, the authors uncovered the earliest mesothelium progenitor cells in zebrafish, linking Hand2 gene function to mesothelium formation and its re-activation to mesothelioma tumors.
