Palladium-Catalyzed <i>β</i>-C(sp<sup>3</sup>)–H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands
Ziting Xu,
Zhi Li,
Chong Liu,
Ke Yang,
Haibo Ge
Affiliations
Ziting Xu
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China
Zhi Li
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China
Chong Liu
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA
Ke Yang
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China
Haibo Ge
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA
2-Pyridone ligand-facilitated palladium-catalyzed direct C–H bond functionalization via the transient directing group strategy has become an attractive topic. Here, we report a Pd-catalyzed direct β-C(sp3)–H arylation reaction of tertiary aliphatic aldehydes by using an α-amino acid as a transient directing group in combination with a 2-pyridone ligand.
