Nature Communications (Mar 2021)

The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis

  • Xia-lian Wu,
  • Hong Hu,
  • Xing-qi Dong,
  • Jing Zhang,
  • Jian Wang,
  • Charles D. Schwieters,
  • Jing Liu,
  • Guo-xiang Wu,
  • Bing Li,
  • Jing-yu Lin,
  • Hua-yi Wang,
  • Jun-xia Lu

DOI
https://doi.org/10.1038/s41467-021-21881-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Receptor Interacting Protein Kinase 3 (RIPK3) has a key role in TNF-induced necroptosis. Here, the authors combine solid state NMR measurements, MD simulations and cell based assays to characterize mouse RIPK3 and they present the structure of the RIPK3 amyloid core.