Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism

Zheng Fu; Joseph W. Dean; Lifeng Xiong; Michael W. Dougherty; Kristen N. Oliff; Zong-ming E. Chen; Christian Jobin; Timothy J. Garrett; Liang Zhou

doi:10.1038/s41467-021-24755-9

Nature Communications (Jul 2021)

Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism

Zheng Fu,
Joseph W. Dean,
Lifeng Xiong,
Michael W. Dougherty,
Kristen N. Oliff,
Zong-ming E. Chen,
Christian Jobin,
Timothy J. Garrett,
Liang Zhou

Affiliations

Zheng Fu: Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida
Joseph W. Dean: Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida
Lifeng Xiong: Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida
Michael W. Dougherty: Department of Medicine, University of Florida
Kristen N. Oliff: Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida
Zong-ming E. Chen: Department of Laboratory Medicine and Pathology, Mayo Clinic
Christian Jobin: Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida
Timothy J. Garrett: Department of Pathology, Immunology and Laboratory Medicine, University of Florida
Liang Zhou: Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida

DOI: https://doi.org/10.1038/s41467-021-24755-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

RORγt is known to play critical roles in the regulation of a number of immune cell subsets. Here the authors implicate mitochondrial transcription factor A in the regulation of intestinal RORγt + lymphocyte homeostasis and metabolic control in a murine in vivo model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal