Nature Communications (Jun 2021)
SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care
- Clemens Gutmann,
- Kaloyan Takov,
- Sean A. Burnap,
- Bhawana Singh,
- Hashim Ali,
- Konstantinos Theofilatos,
- Ella Reed,
- Maria Hasman,
- Adam Nabeebaccus,
- Matthew Fish,
- Mark JW. McPhail,
- Kevin O’Gallagher,
- Lukas E. Schmidt,
- Christian Cassel,
- Marieke Rienks,
- Xiaoke Yin,
- Georg Auzinger,
- Salvatore Napoli,
- Salma F. Mujib,
- Francesca Trovato,
- Barnaby Sanderson,
- Blair Merrick,
- Umar Niazi,
- Mansoor Saqi,
- Konstantina Dimitrakopoulou,
- Rafael Fernández-Leiro,
- Silke Braun,
- Romy Kronstein-Wiedemann,
- Katie J. Doores,
- Jonathan D. Edgeworth,
- Ajay M. Shah,
- Stefan R. Bornstein,
- Torsten Tonn,
- Adrian C. Hayday,
- Mauro Giacca,
- Manu Shankar-Hari,
- Manuel Mayr
Affiliations
- Clemens Gutmann
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Kaloyan Takov
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Sean A. Burnap
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Bhawana Singh
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Hashim Ali
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Konstantinos Theofilatos
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Ella Reed
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Maria Hasman
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Adam Nabeebaccus
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Matthew Fish
- Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London
- Mark JW. McPhail
- King’s College Hospital NHS Foundation Trust
- Kevin O’Gallagher
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Lukas E. Schmidt
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Christian Cassel
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Marieke Rienks
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Xiaoke Yin
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Georg Auzinger
- King’s College Hospital NHS Foundation Trust
- Salvatore Napoli
- Department of Inflammation Biology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King’s College London
- Salma F. Mujib
- Institute of Liver Studies, King’s College Hospital
- Francesca Trovato
- King’s College Hospital NHS Foundation Trust
- Barnaby Sanderson
- Department of Intensive Care Medicine, Guy’s and St Thomas’ NHS Foundation Trust
- Blair Merrick
- Clinical Infection and Diagnostics Research group, Department of Infection, Guy’s and St Thomas’ NHS Foundation Trust
- Umar Niazi
- NIHR Biomedical Research Centre, Guy’s and St Thomas’ NHS Foundation Trust and King’s College London
- Mansoor Saqi
- NIHR Biomedical Research Centre, Guy’s and St Thomas’ NHS Foundation Trust and King’s College London
- Konstantina Dimitrakopoulou
- NIHR Biomedical Research Centre, Guy’s and St Thomas’ NHS Foundation Trust and King’s College London
- Rafael Fernández-Leiro
- Structural Biology Programme, Spanish National Cancer Research Centre (CNIO)
- Silke Braun
- Medical Clinic I, University Hospital Carl Gustav Carus, Technical University Dresden
- Romy Kronstein-Wiedemann
- Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Technical University Dresden
- Katie J. Doores
- Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London
- Jonathan D. Edgeworth
- Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London
- Ajay M. Shah
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Stefan R. Bornstein
- Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technical University Dresden
- Torsten Tonn
- Experimental Transfusion Medicine, Faculty of Medicine Carl Gustav Carus, Technical University Dresden
- Adrian C. Hayday
- Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London
- Mauro Giacca
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- Manu Shankar-Hari
- Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London
- Manuel Mayr
- King’s College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences
- DOI
- https://doi.org/10.1038/s41467-021-23494-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Here the authors use RT-qPCR and mass spectrometry to analyze longitudinal blood samples from intensive care unit (ICU) COVID-19 patients and controls. They find that viral RNA and pentraxin-3 predict 28-day ICU mortality and that galectin-3-binding protein is an interaction partner of SARS-CoV-2 spike glycoprotein with antiviral properties.
