Nature Communications (May 2021)
Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition
- Federica Verginelli,
- Alberto Pisacane,
- Gennaro Gambardella,
- Antonio D’Ambrosio,
- Ermes Candiello,
- Marco Ferrio,
- Mara Panero,
- Laura Casorzo,
- Silvia Benvenuti,
- Eliano Cascardi,
- Rebecca Senetta,
- Elena Geuna,
- Andrea Ballabio,
- Filippo Montemurro,
- Anna Sapino,
- Paolo M. Comoglio,
- Carla Boccaccio
Affiliations
- Federica Verginelli
- Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS
- Alberto Pisacane
- Unit of Pathology, Candiolo Cancer Institute, FPO-IRCCS
- Gennaro Gambardella
- Telethon Institute of Genetics and Medicine (TIGEM)
- Antonio D’Ambrosio
- Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS
- Ermes Candiello
- Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS
- Marco Ferrio
- Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS
- Mara Panero
- Unit of Pathology, Candiolo Cancer Institute, FPO-IRCCS
- Laura Casorzo
- Unit of Pathology, Candiolo Cancer Institute, FPO-IRCCS
- Silvia Benvenuti
- Laboratory of Exploratory Research and Molecular Cancer Therapy, Candiolo Cancer Institute, FPO-IRCCS
- Eliano Cascardi
- Unit of Pathology, Candiolo Cancer Institute, FPO-IRCCS
- Rebecca Senetta
- Unit of Pathology, Candiolo Cancer Institute, FPO-IRCCS
- Elena Geuna
- Multidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS
- Andrea Ballabio
- Telethon Institute of Genetics and Medicine (TIGEM)
- Filippo Montemurro
- Multidisciplinary Oncology Outpatient Clinic, Candiolo Cancer Institute, FPO-IRCCS
- Anna Sapino
- Unit of Pathology, Candiolo Cancer Institute, FPO-IRCCS
- Paolo M. Comoglio
- Laboratory of Exploratory Research and Molecular Cancer Therapy, Candiolo Cancer Institute, FPO-IRCCS
- Carla Boccaccio
- Laboratory of Cancer Stem Cell Research, Candiolo Cancer Institute, FPO-IRCCS
- DOI
- https://doi.org/10.1038/s41467-021-22643-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Cancer of unknown primary (CUP) is a mysterious malignancy featuring metastatic dissemination in the absence of a recognizable primary tumor. By characterizing CUP cancer stem cells we show that self-sustained long-term propagation and sensitivity to MEK inhibition are CUP common features.
