Claisened Hexafluoro Inhibits Metastatic Spreading of Amoeboid Melanoma Cells

Angela Leo; Erica Pranzini; Laura Pietrovito; Elisa Pardella; Matteo Parri; Paolo Cirri; Gennaro Bruno; Maura Calvani; Silvia Peppicelli; Eugenio Torre; Maiko Sasaki; Lily Yang; Lei Zhu; Paola Chiarugi; Giovanni Raugei; Jack L. Arbiser; Maria Letizia Taddei

doi:10.3390/cancers13143551

Cancers (Jul 2021)

Claisened Hexafluoro Inhibits Metastatic Spreading of Amoeboid Melanoma Cells

Angela Leo,
Erica Pranzini,
Laura Pietrovito,
Elisa Pardella,
Matteo Parri,
Paolo Cirri,
Gennaro Bruno,
Maura Calvani,
Silvia Peppicelli,
Eugenio Torre,
Maiko Sasaki,
Lily Yang,
Lei Zhu,
Paola Chiarugi,
Giovanni Raugei,
Jack L. Arbiser,
Maria Letizia Taddei

Affiliations

Angela Leo: Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Erica Pranzini: Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Laura Pietrovito: Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Elisa Pardella: Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Matteo Parri: Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Paolo Cirri: Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Gennaro Bruno: Division of Pediatric Oncology/Hematology, Meyer University Children’s Hospital, 50139 Florence, Italy
Maura Calvani: Division of Pediatric Oncology/Hematology, Meyer University Children’s Hospital, 50139 Florence, Italy
Silvia Peppicelli: Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Eugenio Torre: Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Maiko Sasaki: Department of Dermatology, Emory School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
Lily Yang: Department of Dermatology, Emory School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
Lei Zhu: Department of Dermatology, Emory School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
Paola Chiarugi: Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Giovanni Raugei: Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Jack L. Arbiser: Department of Dermatology, Emory School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
Maria Letizia Taddei: Department of Experimental and Clinical Medicine, University of Florence, Viale Morgagni 50, 50134 Florence, Italy

DOI: https://doi.org/10.3390/cancers13143551
Journal volume & issue: Vol. 13, no. 14
p. 3551

Abstract

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Metastatic melanoma is characterized by poor prognosis and a low free-survival rate. Thanks to their high plasticity, melanoma cells are able to migrate exploiting different cell motility strategies, such as the rounded/amoeboid-type motility and the elongated/mesenchymal-type motility. In particular, the amoeboid motility strongly contributes to the dissemination of highly invasive melanoma cells and no treatment targeting this process is currently available for clinical application. Here, we tested Claisened Hexafluoro as a novel inhibitor of the amoeboid motility. Reported data demonstrate that Claisened Hexafluoro specifically inhibits melanoma cells moving through amoeboid motility by deregulating mitochondrial activity and activating the AMPK signaling. Moreover, Claisened Hexafluoro is able to interfere with the adhesion abilities and the stemness features of melanoma cells, thus decreasing the in vivo metastatic process. This evidence may contribute to pave the way for future possible therapeutic applications of Claisened Hexafluoro to counteract metastatic melanoma dissemination.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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