Nature Communications (May 2017)

Zinc is a potent and specific inhibitor of IFN-λ3 signalling

  • Scott A. Read,
  • Kate S. O’Connor,
  • Vijay Suppiah,
  • Chantelle L. E. Ahlenstiel,
  • Stephanie Obeid,
  • Kristina M. Cook,
  • Anthony Cunningham,
  • Mark W. Douglas,
  • Philip J. Hogg,
  • David Booth,
  • Jacob George,
  • Golo Ahlenstiel

DOI
https://doi.org/10.1038/ncomms15245
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

Lambda interferons (IFNL) are involved in the immune response to viral infection. Here the authors show that zinc can interfere with IFNL signalling, and that in HCV patients the rs12979860 polymorphism regulates blood zinc levels and, subsequently, the hepatic immune response.