Stiff-person syndrome with early onset in infancy

Abstract

The case of stiff-person syndrome with benign course in 16-years old patient is presented. The initial clinical signs of the disease were observed in infancy with retarded development of motor functions and skeleton muscle lumps. The diagnosis was made using generally accepted clinical and electromyographical criteria. Aspects of differential diagnosis, pathogenesis and clinical course polymorphism in early-onset cases of the disease are discussed.

Keywords

• stiff-person syndrome
• muscle rigidity
• painful muscle spasms
• early-onset case
• differential diagnosis
• axial muscles
• motor unit hyperactivity
• glutamic acid decarboxylase
• gaba
• electromyography