Nature Communications (Oct 2022)
Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis
Abstract
Kang and colleagues find that plasma membrane flipping of Syntaxin-2 from inside (inhibitory) to outside (relief of inhibition) of pancreatic β-cells helps fine-tune insulin secretion. Increasing this flipping efficiency can alleviate the impaired insulin secretion in diabetes.