He-Ne lasers play a crucial role in ultra-precision measurement and optical sensing across various fields. For many applications based on He-Ne lasers, a higher output power is required to enhance the accuracy and signal-to-noise ratios of the associated optical measurements. However, conventional methods to increase the output power by reducing the diameter of the He-Ne laser discharge capillary inevitably result in higher diffraction losses and constrain the lasing performance. Here, we propose an approach to enhance laser pumping efficiency and output power through optimizing the ratios of He and Ne gasses. The validity of our proposal has been confirmed by both numerical simulations of He-Ne laser plasma discharge processes and experimental demonstrations, showing that the optimal gas ratio increases with the capillary diameter and total gas pressure.