Nature Communications (Apr 2017)
Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells
- Feng Pan,
- Thomas S. Wingo,
- Zhigang Zhao,
- Rui Gao,
- Hideki Makishima,
- Guangbo Qu,
- Li Lin,
- Miao Yu,
- Janice R. Ortega,
- Jiapeng Wang,
- Aziz Nazha,
- Li Chen,
- Bing Yao,
- Can Liu,
- Shi Chen,
- Ophelia Weeks,
- Hongyu Ni,
- Brittany Lynn Phillips,
- Suming Huang,
- Jianlong Wang,
- Chuan He,
- Guo-Min Li,
- Tomas Radivoyevitch,
- Iannis Aifantis,
- Jaroslaw P. Maciejewski,
- Feng-Chun Yang,
- Peng Jin,
- Mingjiang Xu
Affiliations
- Feng Pan
- Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
- Thomas S. Wingo
- Departments of Human Genetics, Emory University School of Medicine
- Zhigang Zhao
- Department of Hematology and Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy
- Rui Gao
- Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
- Hideki Makishima
- Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Guangbo Qu
- Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
- Li Lin
- Departments of Human Genetics, Emory University School of Medicine
- Miao Yu
- Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago
- Janice R. Ortega
- Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine
- Jiapeng Wang
- Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine
- Aziz Nazha
- Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Li Chen
- Departments of Human Genetics, Emory University School of Medicine
- Bing Yao
- Departments of Human Genetics, Emory University School of Medicine
- Can Liu
- Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
- Shi Chen
- Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
- Ophelia Weeks
- Department of Biological Sciences, Florida International University
- Hongyu Ni
- Department of Pathology, University of Illinois at Chicago
- Brittany Lynn Phillips
- Department of Biochemistry and Pharmacology, Emory University School of Medicine
- Suming Huang
- Department of Biochemistry and Molecular Biology, University of Florida
- Jianlong Wang
- Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai
- Chuan He
- Department of Chemistry and Institute for Biophysical Dynamics, University of Chicago
- Guo-Min Li
- Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine
- Tomas Radivoyevitch
- Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Iannis Aifantis
- Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine
- Jaroslaw P. Maciejewski
- Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Feng-Chun Yang
- Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
- Peng Jin
- Departments of Human Genetics, Emory University School of Medicine
- Mingjiang Xu
- Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
- DOI
- https://doi.org/10.1038/ncomms15102
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
TET2 catalyses DNA demethylation and is mutated in various blood cancers; in particularTet2null mice develop haematological neoplasms. Here the authors show that this effect could be due to the increased frequency of mutation associated with TET2 loss in haematopoietic stem/progenitor cells.
