Nature Communications (Feb 2020)
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
- Phuong-Uyen C. Dinh,
- Dipti Paudel,
- Hayden Brochu,
- Kristen D. Popowski,
- M. Cyndell Gracieux,
- Jhon Cores,
- Ke Huang,
- M. Taylor Hensley,
- Erin Harrell,
- Adam C. Vandergriff,
- Arianna K. George,
- Raina T. Barrio,
- Shiqi Hu,
- Tyler A. Allen,
- Kevin Blackburn,
- Thomas G. Caranasos,
- Xinxia Peng,
- Lauren V. Schnabel,
- Kenneth B. Adler,
- Leonard J. Lobo,
- Michael B. Goshe,
- Ke Cheng
Affiliations
- Phuong-Uyen C. Dinh
- Department of Molecular Biomedical Sciences, North Carolina State University
- Dipti Paudel
- Department of Molecular and Structural Biochemistry, North Carolina State University
- Hayden Brochu
- Department of Molecular Biomedical Sciences, North Carolina State University
- Kristen D. Popowski
- Department of Molecular Biomedical Sciences, North Carolina State University
- M. Cyndell Gracieux
- Department of Molecular and Structural Biochemistry, North Carolina State University
- Jhon Cores
- Comparative Medicine Institute, North Carolina State University
- Ke Huang
- Department of Molecular Biomedical Sciences, North Carolina State University
- M. Taylor Hensley
- Department of Molecular Biomedical Sciences, North Carolina State University
- Erin Harrell
- Department of Molecular Biomedical Sciences, North Carolina State University
- Adam C. Vandergriff
- Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University
- Arianna K. George
- Department of Molecular and Structural Biochemistry, North Carolina State University
- Raina T. Barrio
- Department of Biological Sciences, North Carolina State University
- Shiqi Hu
- Department of Molecular Biomedical Sciences, North Carolina State University
- Tyler A. Allen
- Department of Molecular Biomedical Sciences, North Carolina State University
- Kevin Blackburn
- Department of Molecular and Structural Biochemistry, North Carolina State University
- Thomas G. Caranasos
- Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill
- Xinxia Peng
- Department of Molecular Biomedical Sciences, North Carolina State University
- Lauren V. Schnabel
- Comparative Medicine Institute, North Carolina State University
- Kenneth B. Adler
- Department of Molecular Biomedical Sciences, North Carolina State University
- Leonard J. Lobo
- Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill
- Michael B. Goshe
- Department of Molecular and Structural Biochemistry, North Carolina State University
- Ke Cheng
- Department of Molecular Biomedical Sciences, North Carolina State University
- DOI
- https://doi.org/10.1038/s41467-020-14344-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease and adult lung spheroid cells have been shown to promote regeneration in animal models of IPF. Here the authors show that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells.
