Raised Serum Uric Acid as a Predictor of Perinatal Outcome in Parturient with Pregnancy Induced Hypertension

Abstract

Objective: To evaluate the association of increased uric acid in pregnancy-induced hypertension with adverse perinatal outcomes. Study Design: Comparative cross-sectional study. Place and Duration of Study: Departments of Anesthesia, Gynecology & Obstetrics, Combined Military Hospital, Okara Pakistan, from Mar to Sep 2018. Methodology: After approval of the Hospital Ethical Committee, 106 patients with pregnancy-induced hypertension were included in our study (n=53 in each group). Group-A had patient with raised uric acid, whereas Group-B had normal uric acid. Perinatal outcomes were monitored prospectively. Results: There was no difference in demographic profile of the two study groups. Raised uric acid was shown to be associated with a higher cesarean mode of delivery (p=0.014); preterm delivery (0.001); intrauterine growth retardation (0.038); and low APGAR at 5mintues (0.008). Raised uric had a sensitivity greater than 65% and specificity greater than 50% for perinatal outcomes. Conclusion: Raised uric acid is associated with adverse perinatal outcomes in neonates.

Keywords

• AGPAR score
• Cesarean section
• Intrauterine death
• Intrauterine growth retardation
• Preterm delivery
• Raised uric acid