Clinical Epidemiology (Mar 2022)

Association of Sleep Duration, Midday Napping with Atrial Fibrillation in Patients with Hypertension

  • Xiong Y,
  • Yu Y,
  • Cheng J,
  • Zhou W,
  • Bao H,
  • Cheng X

Journal volume & issue
Vol. Volume 14
pp. 385 – 393

Abstract

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Yurong Xiong,1,2,* Yun Yu,1,2,* Jianduan Cheng,3 Wei Zhou,2,4 Huihui Bao,1,2,4 Xiaoshu Cheng1,2,4 1Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 2Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center, Nanchang, Jiangxi, People’s Republic of China; 3Wuyuan Chinese Medicine Hospital, Shangrao, Jiangxi, People’s Republic of China; 4Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huihui Bao; Xiaoshu Cheng, Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, Jiangxi, 330006, People’s Republic of China, Tel +8613870092915 ; +8613607089128, Fax +86-0791-86262262, Email [email protected]; [email protected]: This study aimed to assess the associations of sleep duration, midday napping and the risk of atrial fibrillation (AF) in patients with hypertension.Methods: We conducted a cross-sectional study enrolling 11,524 hypertensive participates from the Chinese Hypertension Registry Study. Information on sleep duration and midday napping were obtained by a self-administered questionnaire. Multivariate logistic regression analyses were performed to estimate odds ratio (OR) and 95% confidence intervals (CIs) for the risk of AF.Results: Compared with sleeping 6 to ≤ 8 hours/night, those reporting shorter sleep duration (≤ 5 hours/night) had a greater risk of AF (OR 1.95; 95% CI 1.28– 2.95) in the fully adjusted model, while longer sleep (≥ 9 hours/night) was not significantly associated with the risk of AF. Compared with nonhabitual nappers, nappers had a higher risk of AF (OR 1.28; 95% CI 1.03– 1.60) in the fully adjusted model. Moreover, we observed significant joint effects of sleeping ≤ 5 hours/night and nap (OR 2.13; 95% CI 1.09– 4.14) on the risk of AF after adjusting for confounding factors.Conclusion: Short sleep duration and midday napping were independently and jointly associated with higher risks of AF in patients with hypertension.Keywords: sleep medicine, midday napping, atrial fibrillation, hypertension

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