Guoji Yanke Zazhi (Dec 2013)

Preliminary study on the immunology pathogenesis of ocular myasthenia gravis in children

  • Li-Jun Zhou,
  • Ping Wang,
  • Jun-Fang Yang,
  • Xiao-Rong Tang,
  • Zi-Feng Deng,
  • Jin-Mei Zhang

DOI
https://doi.org/10.3980/j.issn.1672-5123.2013.12.55
Journal volume & issue
Vol. 13, no. 12
pp. 2540 – 2542

Abstract

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AIM: To discuss the role of humoral immunity and cellular immunity in the development of ocular myasthenia gravis in children by analyzing the clinical value of the indices including immunoglobulin, complement and T cell subgroup in peripheral blood. METHODS: The concentrations of serum IgG, IgA, IgM, C3 and C4 in the myasthenia gravis group and the control group were detected by immune compare turbid. The contents of CD3+T cell, CD4+T cell and CD8+T cell were detected by flow cytometry. Data was analyzed by Independent-Sample Test.RESULTS: There were no significant differences in contents of IgA, IgM, CD3+T cell, CD8+T cell between ocular myasthenia gravis group in children and the control group(P>0.05). The concentrations of serum IgG, C3 and C4 for myasthenia gravis group were lower than those of the control group(P+T cell were higher than those of the control group(PCONCLUSION: Complement C3, C4 and CD4+T cell played an important role in immunology pathogenesis mechanism for ocular myasthenia gravis in children.

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