Nature Communications (Apr 2021)

Therapeutic B-cell depletion reverses progression of Alzheimer’s disease

  • Ki Kim,
  • Xin Wang,
  • Emeline Ragonnaud,
  • Monica Bodogai,
  • Tomer Illouz,
  • Marisa DeLuca,
  • Ross A. McDevitt,
  • Fedor Gusev,
  • Eitan Okun,
  • Evgeny Rogaev,
  • Arya Biragyn

DOI
https://doi.org/10.1038/s41467-021-22479-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Alzheimer’s disease is characterized by progressive dementia and amyloid beta plaque deposition. Here the authors show in three relevant transgenic animal models that accumulation of activated B cells is central to AD pathology and depletion of B cells interferes with both histological and behavioural manifestations of the disease.