SARS-CoV-2 with Panton-Valentine leukocidin-producing Staphylococcus aureus healthcare-associated pneumonia in the Indian Ocean
Nicolas Allou,
Jérome Allyn,
Nicolas Traversier,
Marie Baron,
Renaud Blondé,
Céline Dupieux,
Nathalie Coolen-Allou,
Julien Jabot,
Guillaume Miltgen
Affiliations
Nicolas Allou
Réanimation Polyvalente, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France; Département d’Informatique Clinique, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France; Corresponding author.
Jérome Allyn
Réanimation Polyvalente, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France; Département d’Informatique Clinique, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France
Nicolas Traversier
Microbiologie, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France
Marie Baron
Réanimation Polyvalente, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France
Renaud Blondé
Réanimation Polyvalente, Centre Hospitalier Mamoudzou, Route de l'hôpital, 97600, Mamoudzou, France
Céline Dupieux
Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Hospices Civils de Lyon, 69004, Lyon, France
Nathalie Coolen-Allou
Pneumologie, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France
Julien Jabot
Réanimation Polyvalente, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France
Guillaume Miltgen
Microbiologie, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, 97405, Saint Denis, France; UMR PIMIT, Processus Infectieux en Milieu Insulaire Tropical, CNRS 9192, INSERM U1187, IRD 249, Université de La Réunion, 97490, Sainte-Clotilde, France; Regional Antibiotic Therapy Center (CRAtb) of Réunion, France
At this time, the literature reports only one case of superinfection with Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus in a patient with severe acute respiratory distress syndrome secondary to coronavirus 2 (SARS-CoV-2) pneumonia. Here we report the first two cases of PVL-producing S. aureus healthcare-associated pneumonia in patients hospitalized for SARS-CoV-2 pneumonia in the Indian Ocean region. The two isolated strains of S. aureus were found to belong to the ST152/t355 clone, a known PVL-producing S. aureus clone that circulates in Africa and is responsible for infections imported into Europe. Our two cases reinforce the hypothesis that SARS-CoV-2 infection favors the occurrence of PVL-producing S. aureus pneumonia. Production of PVL should be searched in patients returning from the Indian Ocean region who present with severe SARS-CoV-2 pneumonia complicated by superinfection with S. aureus even in the case of late onset healthcare-associated pneumonia
