Nature Communications (Oct 2022)

Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort study

  • Madhumita Shrotri,
  • Ellen Fragaszy,
  • Vincent Nguyen,
  • Annalan M. D. Navaratnam,
  • Cyril Geismar,
  • Sarah Beale,
  • Jana Kovar,
  • Thomas E. Byrne,
  • Wing Lam Erica Fong,
  • Parth Patel,
  • Anna Aryee,
  • Isobel Braithwaite,
  • Anne M. Johnson,
  • Alison Rodger,
  • Andrew C. Hayward,
  • Robert W. Aldridge

DOI
https://doi.org/10.1038/s41467-022-33550-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 10

Abstract

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Vaccination can provide reliable and long-lasting protection against COVID-19, however the immune response to vaccination can vary between individuals and can decline over time, leading to differences in protective effects. Here the authors assess the immune response to COVID-19 vaccination across a large cohort of previously uninfected adults and demonstrate lower post-vaccination antibody levels amongst those with immune-suppressing conditions and medications, as well as those with several other more common chronic conditions.