Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort study

Madhumita Shrotri; Ellen Fragaszy; Vincent Nguyen; Annalan M. D. Navaratnam; Cyril Geismar; Sarah Beale; Jana Kovar; Thomas E. Byrne; Wing Lam Erica Fong; Parth Patel; Anna Aryee; Isobel Braithwaite; Anne M. Johnson; Alison Rodger; Andrew C. Hayward; Robert W. Aldridge

doi:10.1038/s41467-022-33550-z

Nature Communications (Oct 2022)

Spike-antibody responses to COVID-19 vaccination by demographic and clinical factors in a prospective community cohort study

Madhumita Shrotri,
Ellen Fragaszy,
Vincent Nguyen,
Annalan M. D. Navaratnam,
Cyril Geismar,
Sarah Beale,
Jana Kovar,
Thomas E. Byrne,
Wing Lam Erica Fong,
Parth Patel,
Anna Aryee,
Isobel Braithwaite,
Anne M. Johnson,
Alison Rodger,
Andrew C. Hayward,
Robert W. Aldridge

Affiliations

Madhumita Shrotri: Institute of Health Informatics, University College London
Ellen Fragaszy: Institute of Health Informatics, University College London
Vincent Nguyen: Institute of Health Informatics, University College London
Annalan M. D. Navaratnam: Institute of Health Informatics, University College London
Cyril Geismar: Institute of Health Informatics, University College London
Sarah Beale: Institute of Epidemiology and Health Care, University College London
Jana Kovar: Institute of Epidemiology and Health Care, University College London
Thomas E. Byrne: Institute of Health Informatics, University College London
Wing Lam Erica Fong: Institute of Health Informatics, University College London
Parth Patel: Institute of Health Informatics, University College London
Anna Aryee: Institute of Health Informatics, University College London
Isobel Braithwaite: Institute of Health Informatics, University College London
Anne M. Johnson: Institute for Global Health, University College London
Alison Rodger: Institute for Global Health, University College London
Andrew C. Hayward: Institute of Epidemiology and Health Care, University College London
Robert W. Aldridge: Institute of Health Informatics, University College London

DOI: https://doi.org/10.1038/s41467-022-33550-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Vaccination can provide reliable and long-lasting protection against COVID-19, however the immune response to vaccination can vary between individuals and can decline over time, leading to differences in protective effects. Here the authors assess the immune response to COVID-19 vaccination across a large cohort of previously uninfected adults and demonstrate lower post-vaccination antibody levels amongst those with immune-suppressing conditions and medications, as well as those with several other more common chronic conditions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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