Communications Biology (Jun 2022)

Activated-memory T cells influence naïve T cell fate: a noncytotoxic function of human CD8 T cells

  • Kazuki Sasaki,
  • Mouhamad Al Moussawy,
  • Khodor I. Abou-Daya,
  • Camila Macedo,
  • Amira Hosni-Ahmed,
  • Silvia Liu,
  • Mariam Juya,
  • Alan F. Zahorchak,
  • Diana M. Metes,
  • Angus W. Thomson,
  • Fadi G. Lakkis,
  • Hossam A. Abdelsamed

DOI
https://doi.org/10.1038/s42003-022-03596-2
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 15

Abstract

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Human activated memory CD8 T cells develop a non-cytotoxic function and influence the fate of autologous naïve CD8 T cells where they acquire an activated/memory state and a hybrid state between naïve and activated memory.