Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2

Takashi Yokoyama; Tomoyasu Nishimura; Yoshifumi Uwamino; Kenjiro Kosaki; Koichi Furusaki; Rumiko Onishi; Takashi Onodera; Makoto Haritani; Katsuaki Sugiura; Rikio Kirisawa; Naoki Hasegawa

doi:10.3390/microorganisms9102096

Microorganisms (Oct 2021)

Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2

Takashi Yokoyama,
Tomoyasu Nishimura,
Yoshifumi Uwamino,
Kenjiro Kosaki,
Koichi Furusaki,
Rumiko Onishi,
Takashi Onodera,
Makoto Haritani,
Katsuaki Sugiura,
Rikio Kirisawa,
Naoki Hasegawa

Affiliations

Takashi Yokoyama: Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
Tomoyasu Nishimura: Department of Infectious Diseases, Keio University School of Medicine, Tokyo 160-8582, Japan
Yoshifumi Uwamino: Department of Infectious Diseases, Keio University School of Medicine, Tokyo 160-8582, Japan
Kenjiro Kosaki: Center for Medical Genetics, Keio University School of Medicine, Tokyo 160-8582, Japan
Koichi Furusaki: Mineral Activation Technical Research Center, Kumamoto 865-0023, Japan
Rumiko Onishi: Santa Mineral Co., Ltd., Tokyo 105-0013, Japan
Takashi Onodera: Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
Makoto Haritani: Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
Katsuaki Sugiura: Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
Rikio Kirisawa: Laboratory of Veterinary Virology, Department of Pathobiology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido 069-8501, Japan
Naoki Hasegawa: Department of Infectious Diseases, Keio University School of Medicine, Tokyo 160-8582, Japan

DOI: https://doi.org/10.3390/microorganisms9102096
Journal volume & issue: Vol. 9, no. 10
p. 2096

Abstract

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Here, the virucidal effect of calcium bicarbonate with a mesoscopic structure (CAC-717) on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was determined. Assays showed that CAC-717 had a strong virucidal effect on all examined SARS-CoV-2 isolates, including variant strains. The viral infectivity decreased within 15 s, and the virucidal activity of CAC-717 at a 1:49 ratio was similar to that of ethanol disinfectant. CAC-717 neutralization eliminated this virucidal effect, indicating that the alkaline condition of CAC-717 is important for virus inactivation and is an indicator of its mesoscopic structure and virucidal activity. The virucidal effect was observed in the presence of organic matter (bovine serum albumin). CAC-717 is a non-invasive and non-flammable substance with a low environmental burden, and its usefulness as a novel disinfectant has been confirmed.

Published in Microorganisms

ISSN: 2076-2607 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.mdpi.com/journal/microorganisms

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