Automated and integrated ultrahigh throughput screening for industrial strain enabled by acoustic-droplet-ejection mass spectrometry

• Zhidan Zhang,
• Chao Zhang,
• Xu Zhang,
• Jiuzhou Chen,
• Ningyun Cai,
• Shasha Zhong,
• Zhibo Han,
• Yan Zhu,
• Ping Zheng,
• Jibin Sun,
• Changxiao Liu

Affiliations

Zhidan Zhang

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 117004, China; Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Systems Biology Centre, Technical Support Core Facilities, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China

Chao Zhang

Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Systems Biology Centre, Technical Support Core Facilities, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China

Xu Zhang

Institute of Traditional Chinese Medicine, University of Traditional Chinese Medicine, Tianjin, 301617, China

Jiuzhou Chen

Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Systems Biology Centre, Technical Support Core Facilities, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China

Ningyun Cai

College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China

Shasha Zhong

College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China

Zhibo Han

College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China

Yan Zhu

Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Systems Biology Centre, Technical Support Core Facilities, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China

Ping Zheng

Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Systems Biology Centre, Technical Support Core Facilities, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; Corresponding author.

Jibin Sun

Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Systems Biology Centre, Technical Support Core Facilities, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China; Corresponding author.

Changxiao Liu

School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 117004, China; State Key Laboratory of Drug Delivery and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin, 300301, China; Corresponding author. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 117004, China.