Nature Communications (Jul 2017)
Quantitative real-time imaging of glutathione
- Xiqian Jiang,
- Jianwei Chen,
- Aleksandar Bajić,
- Chengwei Zhang,
- Xianzhou Song,
- Shaina L. Carroll,
- Zhao-Lin Cai,
- Meiling Tang,
- Mingshan Xue,
- Ninghui Cheng,
- Christian P. Schaaf,
- Feng Li,
- Kevin R. MacKenzie,
- Allan Chris M. Ferreon,
- Fan Xia,
- Meng C. Wang,
- Mirjana Maletić-Savatić,
- Jin Wang
Affiliations
- Xiqian Jiang
- Department of Pharmacology and Chemical Biology, Baylor College of Medicine
- Jianwei Chen
- Department of Pharmacology and Chemical Biology, Baylor College of Medicine
- Aleksandar Bajić
- Department of Pediatrics, Baylor College of Medicine
- Chengwei Zhang
- Department of Pharmacology and Chemical Biology, Baylor College of Medicine
- Xianzhou Song
- Department of Pharmacology and Chemical Biology, Baylor College of Medicine
- Shaina L. Carroll
- Department of Pharmacology and Chemical Biology, Baylor College of Medicine
- Zhao-Lin Cai
- Department of Neuroscience, Baylor College of Medicine
- Meiling Tang
- Department of Pharmacology and Chemical Biology, Baylor College of Medicine
- Mingshan Xue
- Department of Neuroscience, Baylor College of Medicine
- Ninghui Cheng
- Department of Pediatrics, Baylor College of Medicine
- Christian P. Schaaf
- Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital
- Feng Li
- Department of Molecular and Cellular Biology, Baylor College of Medicine
- Kevin R. MacKenzie
- Center for Drug Discovery, Baylor College of Medicine
- Allan Chris M. Ferreon
- Department of Pharmacology and Chemical Biology, Baylor College of Medicine
- Fan Xia
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Meng C. Wang
- Department of Molecular and Human Genetics, Baylor College of Medicine
- Mirjana Maletić-Savatić
- Department of Pediatrics, Baylor College of Medicine
- Jin Wang
- Department of Pharmacology and Chemical Biology, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/ncomms16087
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Fluorescent sensors for small biomolecules are needed to shed insight into real-time cellular processes. Here the authors develop RealThiol, a sensor that can quantitatively monitor glutathione dynamics in living cells, and measure increased antioxidant capability of activated neurons and glutathione changes during ferroptosis.
