RECURRENT SKIN CANCER AFTER BRACHYTHERAPY IN THE MODE OF DOSE HYPOFRACTIONATION AND SINGLE IRRADIATION

Abstract

Objective: to study the frequency and time of development of recurrent skin cancer after brachytherapy in the mode of dose hypofractionation and single irradiation. Material and Methods: We analysed the results of the examination and treatment of 118 patients with skin cancer stage I-II, of which 60 patients received brachytherapy in the dose hypofractionation mode (group I) and 58 - brachytherapy in a single irradiation mode (group II). Results. As a result of radiation treatment, complete tumor resorption was achieved in 100% of patients in both groups. Within 5 years a relapse was registered in 1 out of 67 (1.5%) exposed lesions in patients from group I; in patients from group II, cancer recurrences were detected in 2 out of 70 (2.85%) tumor foci. Conclusions. Due to the high potential of high-tech brachytherapy for individual choice of dose-time ratio with regard to the anatomical localization of the tumor, its shape and size as well as the nature of the underlying tissues, there is a tendency towards reduction in the number of relapses in patient groups.

Keywords

• radiobiological substantiation
• hypofractionation
• single irradiation
• brachytherapy
• skin cancer