Revista de Ciências Farmacêuticas Básica e Aplicada (Apr 2015)
Thiopental alters long term nociceptive response of young rats
Abstract
The objective of this study was to evaluate the long term nociceptive response determined by use of two general anesthetics, one intravenous and the other inhalatory, in young animals. In the first experiment, the animals of 21 days of age were divided into control (saline) and thiopental (35 mg/kg, i.p.) groups. In the second experiment, rats of the same age were divided in two groups – halothane (2%) and control. In experiment 1, there was difference between groups – reduction of tail-flick latency in the group thiopental (P0.05; F(1,19)=0.032 for the interaction, P>0.05). The results obtained in this study showed that halothane did not alter the nociceptive response in young animals. However, the thiopental induced hyperalgesic response in rats.
