Современная ревматология (Apr 2008)

Varfarin v terapii antifosfolipidnogo sindroma

  • T M Reshetnyak,
  • L V Kondrat'eva,
  • I B Shtivel'band,
  • E L Nasonov

DOI
https://doi.org/10.14412/1996-7012-2008-469
Journal volume & issue
Vol. 2, no. 2
pp. 20 – 31

Abstract

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Opisany farmakokinetika, farmakodinamika i monitoring terapii varfarinom. Rassmotreny voprosy povyshennoy chuvstvitel'nosti chasti patsientov k varfarinu, a imenno assotsiatsiya izbytochnoy gipokoagulyatsii s mutatsiyami v gene tsitokhroma R450 CYP2C9*2 I CYP2C9*3. Summirovany dannye literatury o primenenii varfarina u bol'nykh s antifosfolipidnym sindromom (AFS). Predstavleny dannye, kasayushchiesya intensivnosti antikoagulyantnoy terapii pri AFS. Privedeny rekomendatsii i kommentarii, osnovannye na sobstvennom opyte vedeniya bol'nykh s AFS.