Clinical, Cosmetic and Investigational Dermatology (Dec 2019)

Treatment Resistant Atopic Dermatitis: Challenges and Solutions [Corrigendum]

  • Johnson BB,
  • Franco AI,
  • Beck LA,
  • Prezzano JC

Journal volume & issue
Vol. Volume 12
pp. 931 – 932

Abstract

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Johnson BB, Franco AI, Beck LA, Prezzano JC. Clin Cosmet Investig Dermatol. 2019; 12:181–192.On page 189, Ustekinumab section, “Ustekinumab is a human monoclonal antibody that binds to the shared p40 protein subunit of human IL-12 and IL-23, thereby preventing interaction with their shared receptor.86 It is currently approved for Crohn’s disease, plaque psoriasis, and psoriatic arthritis. In a systematic review of ustekinumab in the treatment of AD including eight cases and two RCTs (n=107), a total of 58% of patients showed improvement in their AD.86 While ustekinumab was well tolerated, it is likely that it may only be effective for a subset of AD patients such as those with early-onset AD and possibly AD subjects of Asian descent.87,88” should read “Ustekinumab is a human monoclonal antibody that binds to the shared p40 protein subunit of human IL-12 and IL-23, thereby preventing interaction with their shared receptor.86 It is currently approved for Crohn’s disease, plaque psoriasis, and psoriatic arthritis. In a systematic review of ustekinumab in the treatment of AD including eight cases and two RCTs (n=107), a total of 54% of patients showed improvement in their AD (not clinically significant).86 While ustekinumab was well tolerated, it is likely that it may only be effective for a subset of AD patients such as those with early-onset AD and possibly AD subjects of Asian descent, though there is little current evidence to support its use.87,88”Following feedback from a reader, we have clarified that the use of ustekinumab in the Pan et al study86 was not clinically significant. The authors apologize for this omission.Read the original article