Study of Protective Properties of Gentamicin in Liposome-Entrapped and Free Forms in Case of Aerogenic Melioidosis Infection

Abstract

Presented are data on investigation of protective properties of free and liposome-entrapped forms of gentamicin against aerogenic infection caused by melioidosis agent. Comparative study identified that immobilization of gentamicin into liposomes increased substantially the ED50 of the preparation. This, probably, can be related to higher sorbtion of liposomal preparation by parenchymal organs including lungs.

Keywords

• melioidosis
• gentamicin
• liposomes