TG: HDL, AST: ALT, A:G Ratios in Alcoholic and Non-alcoholic Fatty Liver patients

Abstract

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is typically first suspected when the results of liver function tests, measured as part of routine testing, are abnormal. Most often observed biochemical pattern in hepatic steatosis due to NAFLD is of increased levels of transaminases, with alanine aminotransferase (ALT) levels exceeding those of aspartate aminotransferase (AST). This classical pattern is particularly useful in differentiating between hepatic steatosis from NAFLD.The pathophysiology of non-metabolic complication like atherosclerosis and cardiovascular disease (CVD) depends vastly on fatty acids (lipid) transportation and Deposition. AIM Estimation of the AST: ALT, Albumin: Globulin, and TG: HDL ratios, along with their comparison among the Alcoholic and Non-alcoholic fatty liver disease patient. Materials & Methods: A prospective observational cohort study was conducted in the department of Biochemistry at GBCM & KKBM Subharti hospital, Jhajra, Dehradun after obtaining the ethical clearance from the institutional ethical committee (IEC) with registration no GBCM/IEC/2023/07-03 dated 25/07/2023. Cases comprised of 120 Ultrasonographically confirmed fatty liver patients by Random sampling method. 5ml blood sample was collected in the serum separation test tube (SST) and results were analysed using SPSS v.20. and statistical p-value of <0.05 was considered to be significant. Results: Extremely significant difference in TG: HDL and A:G ratio was found between two groups with statistical p-value of <0.05 and <0.01 respectively. Conclusion: This study can significantly contribute in evaluating the lipid derangements in two groups and their management.

Keywords

• alcoholic fatty liver
• ast: alt ratio
• a: g ratio
• fatty liver
• tg: hdl ratio
• non-alcoholic fatty liver