Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (Dec 2019)
Rates of age‐ and amyloid β‐associated cortical atrophy in older adults with superior memory performance
- Christa Dang,
- Nawaf Yassi,
- Karra D. Harrington,
- Ying Xia,
- Yen Ying Lim,
- David Ames,
- Simon M. Laws,
- Martha Hickey,
- Stephanie Rainey‐Smith,
- Hamid R. Sohrabi,
- James D. Doecke,
- Jurgen Fripp,
- Olivier Salvado,
- Peter J. Snyder,
- Michael Weinborn,
- Victor L. Villemagne,
- Christopher C. Rowe,
- Colin L. Masters,
- Paul Maruff,
- AIBL Research Group,
- Brian Chambers,
- Edmond Chiu,
- Roger Clarnette,
- David Darby,
- Mary Davison,
- John Drago,
- Peter Drysdale,
- Jacqueline Gilbert,
- Kwang Lim,
- Nicola Lautenschlager,
- Dina LoGiudice,
- Peter McCardle,
- Steve McFarlane,
- Alastair Mander,
- John Merory,
- Daniel O'Connor,
- Ron Scholes,
- Mathew Samuel,
- Darshan Trivedi,
- Michael Woodward
Affiliations
- Christa Dang
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Nawaf Yassi
- The Florey Institute of Neuroscience and Mental Health, The University of MelbourneParkvilleVictoriaAustralia
- Karra D. Harrington
- The Florey Institute of Neuroscience and Mental Health, The University of MelbourneParkvilleVictoriaAustralia
- Ying Xia
- CSIRO Health and Biosecuritythe Australian eHealth Research CentreBrisbaneQueenslandAustralia
- Yen Ying Lim
- The Florey Institute of Neuroscience and Mental Health, The University of MelbourneParkvilleVictoriaAustralia
- David Ames
- Academic Unit for Psychiatry of Old AgeDepartment of PsychiatryThe University of MelbourneParkvilleVictoriaAustralia
- Simon M. Laws
- Cooperative Research Centre for Mental HealthParkvilleVictoriaAustralia
- Martha Hickey
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Stephanie Rainey‐Smith
- Centre of Excellence for Alzheimer's Disease Research and CareSchool of ExerciseBiomedical and Health SciencesEdith Cowan UniversityPerthWestern AustraliaAustralia
- Hamid R. Sohrabi
- Centre of Excellence for Alzheimer's Disease Research and CareSchool of ExerciseBiomedical and Health SciencesEdith Cowan UniversityPerthWestern AustraliaAustralia
- James D. Doecke
- CSIRO Health and Biosecuritythe Australian eHealth Research CentreBrisbaneQueenslandAustralia
- Jurgen Fripp
- CSIRO Health and Biosecuritythe Australian eHealth Research CentreBrisbaneQueenslandAustralia
- Olivier Salvado
- CSIRO Health and Biosecuritythe Australian eHealth Research CentreBrisbaneQueenslandAustralia
- Peter J. Snyder
- George & Anne Ryan Institute for Neuroscience, The University of Rhode IslandKingstonRIUSA
- Michael Weinborn
- Centre of Excellence for Alzheimer's Disease Research and CareSchool of ExerciseBiomedical and Health SciencesEdith Cowan UniversityPerthWestern AustraliaAustralia
- Victor L. Villemagne
- The Florey Institute of Neuroscience and Mental Health, The University of MelbourneParkvilleVictoriaAustralia
- Christopher C. Rowe
- Department of Molecular Imaging & TherapyAustin HealthMelbourneVictoriaAustralia
- Colin L. Masters
- The Florey Institute of Neuroscience and Mental Health, The University of MelbourneParkvilleVictoriaAustralia
- Paul Maruff
- The Florey Institute of Neuroscience and Mental Health, The University of MelbourneParkvilleVictoriaAustralia
- AIBL Research Group
- Brian Chambers
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Edmond Chiu
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Roger Clarnette
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- David Darby
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Mary Davison
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- John Drago
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Peter Drysdale
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Jacqueline Gilbert
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Kwang Lim
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Nicola Lautenschlager
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Dina LoGiudice
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Peter McCardle
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Steve McFarlane
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Alastair Mander
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- John Merory
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Daniel O'Connor
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Ron Scholes
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Mathew Samuel
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Darshan Trivedi
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- Michael Woodward
- Department of Obstetrics and GynaecologyMelbourne Medical School, The University of MelbourneParkvilleVictoriaAustralia
- DOI
- https://doi.org/10.1016/j.dadm.2019.05.005
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 566 – 575
Abstract
Abstract Introduction Superior cognitive performance in older adults may reflect underlying resistance to age‐associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ‐associated neurodegeneration. Methods Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. Results Of the case‐matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age‐ and Aβ‐associated atrophy did not differ between the groups on any measure. Aβ− individuals displayed the slowest rates of atrophy. Discussion Maintenance of superior memory in late life does not reflect resistance to age‐ or Aβ‐associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ−) displayed reduced rates of cortical atrophy.
Keywords
