Эпидемиология и вакцинопрофилактика (May 2022)

Herd Immunity to Hepatitis B in the Russian Federation in 2017–2019

  • S. N. Kuzin,
  • T. A. Semenenko,
  • V. V. Klushkina,
  • N. V. Vlasenko,
  • N. S. Churilova,
  • Ya. V. Panasyuk,
  • E. N. Kudryavtseva,
  • M. I. Korabel'nikova,
  • D. V. Dubodelov,
  • Z. S. Rodionova,
  • G. G. Solopova,
  • M. V. Konopliova,
  • I. G. Nikitin,
  • N. I. Shulakova,
  • A. V. Tutelian,
  • V. G. Akimkin

DOI
https://doi.org/10.31631/2073-3046-2022-21-2-29-37
Journal volume & issue
Vol. 21, no. 2

Abstract

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Relevance. Hepatitis B is a global problem of global and Russian public health due to its high prevalence and the possibility of forming a chronic form of the disease with the development of cirrhosis and hepatocellular carcinoma. Aims. Assessment of the herd immunity to hepatitis B in the population of the Russian Federation in 2017‒2019.Materials and methods. The research was carried out at the Central Institute of Epidemiology within the framework of a large-scale program to assess herd immunity to hepatitis B in the population of the Russian Federation. The results of studies for the presence of anti-HBs in various subjects of the Russian Federation in 2017 to 2019, which were performed in accordance with MU 3.1.2943-11, were analyzed. Additionally, as a reference study in 2020, a survey of donors in Moscow (n = 427) was conducted for the presence of anti-HBs. Standard methods of descriptive statistics Microsoft Excel and STATISTICA 12.0 (StatSoft, USA) were used for statistical processing. The mean values were estimated taking into account the 95% confidence interval [95% CI] (according to the Klopper-Pearson method (exact method).Results. The average annual values of the proportion of persons with protective immunity against hepatitis B for 2017, 2018 and 2019 were 70.03%, 67.95% and 66.36%, respectively. Significant differences were revealed in the average values of the proportion of persons with a protective level of anti-HBs in the Federal Districts (FD): higher than the average Russian indicators were found in the Northwestern (74.2%), Southern (71.0%) and Far Eastern FD (70.7%). In 44 subjects of the Russian Federation during the observation period, the proportion of persons with protective immunity against hepatitis B was less than 60%.Conclusion. The necessity of optimizing the system of serological monitoring of post-vaccination immunity against hepatitis B is substantiated, which will increase the effectiveness of preventive measures nationwide

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