PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Min Xie; Yan Yu; Rui Kang; Shan Zhu; Liangchun Yang; Ling Zeng; Xiaofang Sun; Minghua Yang; Timothy R. Billiar; Haichao Wang; Lizhi Cao; Jianxin Jiang; Daolin Tang

doi:10.1038/ncomms13280

Nature Communications (Oct 2016)

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Min Xie,
Yan Yu,
Rui Kang,
Shan Zhu,
Liangchun Yang,
Ling Zeng,
Xiaofang Sun,
Minghua Yang,
Timothy R. Billiar,
Haichao Wang,
Lizhi Cao,
Jianxin Jiang,
Daolin Tang

Affiliations

Min Xie: Department of Pediatrics, Xiangya Hospital, Central South University
Yan Yu: Department of Pediatrics, Xiangya Hospital, Central South University
Rui Kang: Department of Surgery, University of Pittsburgh
Shan Zhu: Center of DAMP Biology, The Third Affiliated Hospital of Guangzhou Medical University
Liangchun Yang: Department of Pediatrics, Xiangya Hospital, Central South University
Ling Zeng: Department of Surgery, University of Pittsburgh
Xiaofang Sun: Center of DAMP Biology, The Third Affiliated Hospital of Guangzhou Medical University
Minghua Yang: Department of Pediatrics, Xiangya Hospital, Central South University
Timothy R. Billiar: Department of Surgery, University of Pittsburgh
Haichao Wang: Laboratory of Emergency Medicine, The Feinstein Institute for Medical Research
Lizhi Cao: Department of Pediatrics, Xiangya Hospital, Central South University
Jianxin Jiang: State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Research institute for Traffic Medicine of People’s Liberation Army, Daping Hospital, Third Military Medical University
Daolin Tang: Department of Surgery, University of Pittsburgh

DOI: https://doi.org/10.1038/ncomms13280
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Inflammation involves a Warburg effect that switches cellular metabolism to glycolysis. Here the authors show this switch drives IL-1β, IL-18 and HMGB1 release from macrophages by activating the NLRP3 and AIM2 inflammasomes via protein kinase R phosphorylation, a pathway that can be inhibited to prevent sepsis in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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